3D cardiac patches promote myocardial regeneration

3D cardiac patches promote myocardial regeneration

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3D cardiac patches promote myocardial regeneration

Researchers from the Pohang University of Science and Technology in Korea have developed i 3D heart patches derived from stamina cells. Cardiovascular diseases in fact account for 32% of deaths worldwide. Myocardial infarction plays an important role in heart disease and heart tissue necrosis after the blood supply is decreased or interrupted.

3D cardiac patches promote myocardial regeneration

Construction of complex 3D printed tissues using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair, pages 264-274, Copyright (2017), with permission from Elsevier. Schematic illustration of a pre-vascularized stem cell patch with multiple stem cell laden bio-inks.

3D bio-printed heart patch technologies loaded with stem cells and their efficacy as a therapeutic and regenerative approach for ischemic cardiomyopathy in reversing scar formation and promoting myocardial regeneration, are being studied with promising results.

The study was published on APL Bioengineering.

3D heart patches: a promising alternative for myocardial repair

“Currently available therapies are not sufficient for the complete treatment of myocardial infarction”, stated the author Jinah Jang. “The development of a new advanced modality is urgently needed, such as the reduction of adverse cardiac remodeling, the promotion of myocardial functions and the correction of molecular or genetic defects.”

Researchers investigated various candidate stem cell types that possess cardiac regenerative potential, explaining their applications and limitations. the research team focused on the challenging implementation of the state-of-the-art 3D bioprinting approach to fabricate 3D cardiac patches and highlight different strategies to implement vascularization and increase cardiac functional properties compared to electrophysiological similarities to native tissue.

3D cardiac patches promote myocardial regeneration

3D cardiac patches promote myocardial regeneration