Recent research scientists.
This discovery may help scientists develop effective methods for the treatment of vision loss related to early diabetic retinopathy –an eye disease that can lead to vision loss people with diabetes. On the middle and later stages it occurs because of damage to blood vessels in the retina, reports the Chronicle.info with reference to grippua.com.ua.
Usually treatable diabetic retinopathy injections, laser or surgery. Although in the later stages diabetic retinopathy is characterized by damage to blood vessels of the retina, recent studies have shown that in the early stages the patient is in danger of loss of vision without visible damage to the blood vessels.
Vitamin a plays an important role in the normal functioning of view, helping to produce the protein for absorption of light by the retina associated with the chromophore 11-CIS-retinal necessary for optimal vision.
The study authors noted that diabetes can lead to deficiency of vitamin A, besides the experimental rats with diabetes, the level of 11-CIS-retinal was low. Because of this, scientists have speculated about the link between diabetes, vitamin A deficiency and early loss of vision, characteristic in some cases of diabetic retinopathy.
“In earlier research we found that diabetes causes a deficiency of vitamin A in the retina that leads to vision impairment even before the appearance of any vascular changes, says Dr. Gennady Moiseev from the health Sciences Center the University of Oklahoma. – This discovery led to the hypothesis that early vision loss in diabetes is probably caused by a deficiency of vitamin A in the retina”.
To check whether this is true, scientists have studied the efficiency of chromophore-9-CIS-retinal in the treatment of vision loss in mice with diabetes (9-CIS-retinal also produced by the body and is similar to 11-CIS-retinal). One rodent diabetics were administered a dose of 9-CIS-retinal, and the other a placebo. Then analyzed the view of all the mice, by measuring the parameters of the electroretinogram, the death of retinal cells and its oxidative stress.
It was discovered that mice treated with 9-CIS-retinal a, vision improved significantly in all indicators. According to Dr. Moses, “this work confirms our hypothesis that diabetes is caused by the metabolic disorder of vitamin A in the eye that reduces visual function in the early stages of diabetic retinopathy”.
Unfortunately, currently there is no available therapy to prevent the development of complications of the retina in people with diabetes. “This study suggests that the delivery of the chromophore in the eye can be a potential therapeutic strategy in the early stages of diabetic retinopathy to prevent vision loss in diabetics,” – says Dr. Moses.