Here is the third and therefore last part of the story of the journey of a medication.
Find the first part and the second part.
LancetGate and NewEnglandGate : focus on the manipulation of scientific publications
In the past, the French language was the language of communication of the scientific and medical press French had a storefront. It is now virtually non-existent, including in the register of publications in the English language, which is very much in disfavour of the French research teams.
The medical press, as the general press, is now in the hands of industrialists and pension funds, which leads to drifts such as those observed during the pandemic, namely, publication of articles imposed by the publishers, or in the pseudo-circuits of reviewing, either out of the procedure.
Beyond this, it is the entire circuit of the publications that has been perverted, becoming a business is extremely lucrative when it is necessary to have funds available for that your publication is visible, where in the past you postiez your article to a journal that you referred a free opinion and published without consideration if it was deemed scientifically useful.
As an example, today you have the ability to reference an article in the “doi ” for an entrance fee and an annual allowance. If you’re a journal, you will have an interest in having an “impact factor ” and thus to pay the company in charge of this service. If you are a research structure of French who wishes to maintain an allocation from the State, you need to take into account a number of settings, and researchers have interest to collect a maximum of points ” Sigaps “, among others, from publications in high impact factor… Some of the journals affected by the crisis in the paper and circuits open-source, charge a fee to submit an article, officially also to allow for greater independence.
Worse, during the crisis COVID-19 there has clearly been assisted and continues to assist in the blocking of publications serving the interests of certain industries.
The medical press must regroup in order to be credible and also be representative of different countries. Similar to the ranking of the best universities in the world, a press that is asian is being put in place, perhaps this will he clean up the environment. In the meantime, the system of “preprints” gives a certain visibility to the research work condemned by journals on the storefront, some of which have severely tarnished their image with rétractations articles explosive during the pandemic.
Citizens wake up ! Your Health is at the heart of conflicts of interest.
The drug industry must return to the service of the health of citizens and the speculators need to go play elsewhere.
The profitability has led to serious abuses, pushing the French State to interfere in the freedom of prescription of physicians, a first !
One may question on a number of subjects, I will mention that two to think the readers of this article : the flu vaccine and the cholesterol-lowering drugs that are statins.
Madame Sylvie Briand of the WHO stated in a tv studio where I was that it was going to be necessary to vaccinate the people against the coronavirus, that they would not be able to immunize and that it would be necessary to vaccinate every year because of the antibodies obtained by the immunization would not be sustainable. In addition to the fact of terrorizing the people, how this lady, three months after the identification of the genome of the virus, could she do all of these dark predictions, leading to an injunction subliminal vaccination that more is annual. I of course confronted on the subject.
Someone there thought two minutes to find out if vaccinated every year against influenza (for which there is, moreover, no serology screening), is relevant, when we revaccine with exactly the same stem for several years ? Someone there thought about why we had to destroy it for € 400 million vaccines against H1N1 flu during the crisis with the same name ? In my opinion, because the two previous years, had been vaccinated a large proportion of the population with precisely a fragment of the H1N1 virus in the flu vaccine classic…
As a second example, the statin drugs, prescribed, rightly, in the treatment of hypercholesterolemia halted, but more questionable, in “prevention” of cardiovascular risk in patients with normocholesterolemic. In twenty years, there has been a drastic revision of the standards of cholesterol, officially because of the tables prepared by the insurance companies. Someone-it looked at the consequences of these cholesterol levels particularly low in the number of men treated ? For memory, the kernel cholesterol is the basis of the synthesis of the steroid hormones, including testosterone, and this lowering excessive causes in some patients of andropauses early, resulting in fatigue, libido disorders, and other complications which nobody cares about.
I want to, for example, what professor running on a tv set have never touched money in the industry, adding “not even a crescent,” and that the declarations of interest reach a peak of 3941€. Certainly, a small amount in view of the hundreds of thousands of euros of some heads of service who has copiously denied that the results of studies that were not devoid of scientific interest in the treatment in the early phase of patients with COVID-19 and be conducted in a context that is particularly difficult. Worse, these heads of service are, for some, part of the scientific council and/or the High Council of Public Health or of the Committee CARE and have contributed to the opinion versatile to have put in danger the health of citizens.
A new World Health Organization needs to see the light of day, as citizens, and not driven by conflicts of interest.
Physicians must be cautious, realize what it is happening and not rushing to the new drugs, except for therapeutic emergency. Indeed, in the current state of research, it takes between 3 and 5 years to get an idea of the tolerance of a drug in which the pharmacovigilance system has been sloppy.
Physicians should require that the pharmacovigilance post marketing authorisation is properly organized and that the work that is asked of when adverse event reports (often several hours or even several days of work) to be paid in order that physicians may under-report the problems due to lack of time, and this even if the creation of the regional centres of pharmacovigilance has helped to improve the situation.
Pharmacovigilance is a business that requires a lot of skills, rarely met since the ideal profile of the investigator requires almost a double profile physician + pharmacist, unusual !
Pharmacovigilance must continue for years, because the long-term toxic effects are unknown in the beginning of the placing on the market. This is all the more crucial as, in some cases, it gets to manipulate dangerously the functioning of the human body, as is the case for example with monoclonal antibodies, some of which lead, to term, leukemias, lymphomas, and cancers.
The clinical examination, that is to say, the physical examination of the patient, must remain at the heart of the research, without denying the unquestionable interest of numbers investigation techniques. Telemedicine is not a good idea, especially not in R&D. We have seen the damage of this medicine, and of the ” stay at home “, where many patients had been able to be properly treated and guided after a test which would have revealed a lung injury or a friction pericardial fluid.
Let’s stop making e-doctors, high technology, and big data and learn semiology to medical students so that they can make the difference between complications related to coagulation disorders and lung disease.
This crisis of coronavirus has one advantage, that of giving to all the opportunity to reflect on the number of malfunctions. The French citizens must measure the extent to which the destruction of their health system for years has made the management of this complex crisis and led the State to enact a containment that would have to only apply in respect of persons.
This crisis has revealed deficiencies multifactorial and a lot of incompetence. Some, staggered, waved the explanation complotiste and others have ridiculed, without accepting to see the mass of the conflicts of interest that has been unmasked.
In regards to the pharmaceutical industry, certainly, there has been a convergence of interests between multiple actors to discredit a treatment that endangers their business plan, every emergence of a new infectious disease being a market to conquer, that the manufactures of vaccines or drugs.
However, in an emergency situation, the practice of a medicine of land, centred on the care, using available treatments, and whose data pharmacovigilance were known, took on its meaning and legitimacy.
Author(s): Dr Violaine GUERIN for FranceSoir