Atherosclerosis is primarily caused by the deposition of harmful cholesterol and the accumulation of inflammatory cells in the inner wall of the vessels, which subsequently leads to the accumulation of atherosclerotic plaques..
According to a new study published in the journal Nature, researchers in Switzerland from the Universities of Vienna and Lausanne, in cooperation with their colleagues from the University of Cambridge, England, discovered that the protein called “A Prolacing Inducing Ligand” APRIL – APRIL provides essential protection against the formation of atherosclerotic plaques.
Using animal models, the researchers found that ablation of the APR protein exacerbated atherosclerosis in mice, and were also able to show that injections of APR-neutralizing antibodies conferred protection against atherosclerosis..
In this context, first author Dimitros Tsiantolas says: “Our original hypothesis was that APRIL’s ability to regulate the properties of B lymphocytes – which play an essential role in atherosclerosis – protects against the formation of atherosclerotic plaques, but this hypothesis turned out to be wrong. So we resorted to To another – less well-known – non-immune property of “April”, which is the property of its binding to the so-called protein (perlican).“.
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The authors discovered that APRIL is produced in large quantities by the arteries themselves, and there it binds to the protein “perlican”, which is a large molecule, and is considered an integral part of the inner layer of the arteries..
It has previously been shown that the “perlican” protein enhances the deposition of harmful cholesterol in the walls of the blood vessels, but the new study proved that the “April” protein was able to reduce the “perlican” protein, and thus prevent the development of atherosclerosis in mice..
human models
The authors also studied the importance of the APR protein in atherosclerotic vascular disease in humans, using various methods, developed by Pascal Schneider, a senior researcher at the University of Lausanne and a co-author on the study. They called him (nc-APRIL).
By analyzing more than 3,000 patient samples, the scientists were able to show that blood levels in nc-APRIL Predict the risk of death from cardiovascular disease.
This prediction is a strong indication that APRIL binding to Perlican also plays an important role in atherosclerotic cardiovascular disease in humans.
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